Project Summary
The 4 proposed complementary projects examine strategies to augment ketosis interventions to meet the needs of military service members, veterans, and the general population. This program represents the most comprehensive assessment of different methods of achieving physiological levels of ketones (nutritional ketosis) through novel methods that include newly developed ketone esters that do not require any change in diet and well-formulated ketogenic diet delivered using a technology-enabled continuous remote care. New wearable technologies for continuously monitoring ketones will be used across all projects to assess adherence and provide unprecedented opportunities for correlating robust measures of ketosis with performance and clinical outcomes. We have assembled a highly motivated team of multidisciplinary scientists that includes academic, military, clinical, and industry partners. Project 1 evaluates the most effective and deployable KEs that will facilitate the design of next-generation ketone esters molecules to promote health and performance. Project 2 explores ketone esters and ketogenic diets and their impact on cognitive and physical performance in the context of sleep restriction and exercise in cadets. Project 3 explores whether ketone esters and ketogenic diets impact exercise tolerance and cardiac function in patients with type 2 diabetes and heart failure. Project 4 examines a ketogenic diet delivered via a novel tele-medicine platform on progression of chronic kidney disease in individuals with type 2 diabetes.
Investigator(s):
Jeffrey Volek, PhD
Guy Brock, PhD
Audra Hanners, DNP, APRN-CNP, FNP-C, PMHNP-BC, CKNS
Ayesha Hasan, MD
Scott Hayes, PhD
Joshua J. Joseph, MD
Ulysses J. Magalang, MD
Orlando P. Simonetti, PhD
Sponsor
Army Medical Research Acquisition Activity
Award Year
2022
Award Duration
4 years